A First-In-Human Trial of pTTL in Advanced Colorectal Cancer
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ABSTRACT: This is an open-label, non-randomised FIH trial investigating the safety and tolerability of a novel ATMP, pTTL, composed of autologous tumour-draining lymph node-derived T cells stimulated in vitro with personalised cancer neoantigens.
The neoantigens are selected through a process starting with next generation sequencing (NGS) of tumour material from the patient followed by selection of neoantigenic mutations using an in-house software, PIOR. Selected neoantigen epitopes are expressed as recombinant proteins, NAG, and used to stimulate T cells to promote neoantigen-specific T cell expansion in vitro in pTTL production.
pTTL is thus based on autologous cells stimulated with patient-specific neoantigens. In consequence, every pTTL product is unique and designated for use in one single individual.
pTTL will be administered to patients with stage IV colorectal cancer (CRC) as a single intravenous dose.
DISEASE(S): Colorectal Cancer,Colorectal Neoplasms,Stage Iv Colorectal Cancer.
PROVIDER: 63772 | ecrin-mdr-crc |
REPOSITORIES: ECRIN MDR
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