The Immune Effects of Fermented Wheat Germ Nutritional Supplementation in Patients With Advanced Solid Tumor Cancers Being Treated With Standard of Care Checkpoint Inhibitors

ABSTRACT: This phase I clinical trial tests the immune effects of fermented wheat germ in patients with advanced solid tumor cancers who are being treated with standard of care checkpoint inhibitors. Fermented wheat germ is a nutritional supplement that some claim is a "dietary food for special medical purposes for cancer patients" to support them in treatment. There have also been claims that fermented wheat germ is "clinically proven" and "recognized by medical experts" to "enhance oncological treatment" and boost immune response to cancer; however, there are currently no documented therapeutic effects of fermented wheat germ as a nutritional supplement. Checkpoint inhibitors, given as part of standard of care for advanced solid tumors, are a type of immunotherapy that may help the body’s immune system attack the cancer and may interfere with the ability of tumor cells to grow and spread. The information gained from this trial may allow researchers to determine if there is any value of giving fermented wheat germ with standard of care checkpoint inhibitors for patients with advanced solid tumor malignancies.

DISEASE(S): Stage Iii Lung Cancer Ajcc V8,Advanced Triple-negative Breast Carcinoma,Stage Iv Colorectal Cancer Ajcc V8,Carcinoma,Advanced Melanoma,Anatomic Stage Iv Breast Cancer Ajcc V8,Melanoma,Advanced Colorectal Carcinoma,Advanced Malignant Solid Neoplasm,Stage Iii Renal Cell Cancer Ajcc V8,Clinical Stage Iv Cutaneous Melanoma Ajcc V8,Breast Neoplasms,Lung Neoplasms,Advanced Renal Cell Carcinoma,Stage Iv Renal Cell Cancer Ajcc V8,Anatomic Stage Iii Breast Cancer Ajcc V8,Advanced Lung Non-small Cell Carcinoma,Skin Neoplasms,Colorectal Neoplasms,Carcinoma, Renal Cell,Carcinoma, Non-small-cell Lung,Stage Iii Colorectal Cancer Ajcc V8,Clinical Stage Iii Cutaneous Melanoma Ajcc V8,Stage Iv Lung Cancer Ajcc V8

PROVIDER: 68011 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR