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Correlation between immune monotherapy and the evolution of intestinal flora in patients with small cell lung cancer

ABSTRACT: Interventions: Group A:None;Group B:Live Bacillus Licheniformis Capsule;Group C:Live Combined Bacillus Subtilis and Enterocoocus Faecium Enteric-coated Capsules;Group D:Triple Viable Capsules Dissolving at Intestines Primary outcome(s): Overall survival Study Design: Parallel

DISEASE(S): Small Cell Lung Cancer

PROVIDER: 83356 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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The correlation between immunotherapy combined with anti-angiogenesis therapy and the evolution of intestinal flora in small cell lung cancer

Project description:Interventions: Group A:None;Group B:Live Bacillus Licheniformis Capsule;Group C:Live Combined Bacillus Subtilis and Enterocoocus Faecium Enteric-coated Capsules;Group D:Triple Viable Capsules Dissolving at Intestines Primary outcome(s): Overall survival Study Design: Parallel

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The correlation between chemotherapy combined with immunotherapy and the evolution of intestinal flora in small cell lung cancer

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Bacillus licheniformis isolated from Korean traditional food resources enhances the lifespan of Caenorhabditis elegans through serotonin signaling

2015-11-05 | GSE63056 | GEO

Bacillus licheniformis isolated from Korean traditional food resources enhances the lifespan of Caenorhabditis elegans through serotonin signaling

Project description:The C. elegans lifespan in the presence of Bacillus licheniformis caused induction of a large number of genes associated with anti-aging activiy including beta-oxidation Inaddition, these results indicate the B. licheniformis enhances the lifespan of Caenorhabditis elegans through serotonin signaling Two-condition experiment, C. elegans with B. lichemiformis 141 or E. coli OP50 (conrol) for 24 h. For preparing the total RNA, C. elegans were exposed to 20 mg of bacterial lawn in NGN agar for 24 h.

2015-11-05 | E-GEOD-63056 | biostudies-arrayexpress

Effects of Shenlingbaizhu powder on the efficacy of chemotherapy and the quality of life of patients with ovarian cancer based on intestinal microecology

Project description:Interventions: control group:Standard chemotherapy plus Bifid Triple Viable Capsules;Experiment group:Standard chemotherapy plus Shenlingbaizhu powder;Blank group:Standard chemotherapy, no Bifid Triple Viable Capsules Primary outcome(s): Distribution of intestinal flora;Immune function test;Efficacy evaluation Study Design: Parallel

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Clinical study on the sensitization effect of enterobacterin capsule on pd-1 / pd-1l inhibitor of advanced colorectal cancer

Project description:Interventions: Enterobacteria capsule group:Take in 16 enteric capsule ;placebo group :Placebo capsules that are administered orally in the same amount as Enterobacteria capsules Primary outcome(s): ORR Study Design: Parallel

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Bacillus licheniformis meets ulvan: a marine polysaccharide as potential industrial feedstock

Project description:Proteomes of Bacillus licheniformis DSM13 cultivated with glucose, rhamnose as well as ulvan or two ulvan hydrolysates (UHA and UHB). Hydrolysates were generated using selected Formosa agariphila KM3901 ulvan-PUL encoded enzymes.

2022-11-02 | PXD033411 | Pride

Integrative Analysis of Transcriptome and Proteome for a new Rumen-derived Bacillus Licheniform in regulating microenvrionment Treating with Different Carbon Sources

Project description:Bacillus licheniformis (B. licheniformis) is a microorganism with a wide range of probiotic properties and applications. Isolation and identification of novel strains is a major aspect of microbial research. Besides, the role of different carbon sources affects B. licheniformis in regulating micro-environment and the mechanisms need to be further investigated. In this study, we first isolated and identified a new strain of B. licheniformis from bovine rumen fluid. Microcrystalline cellulose (MC) and cellobiose (CB) as the certain carbon sources to treat strain. Further, a combination of transcriptome and proteome analyses was used to different carbon sources effects. The results showed that B. licheniformis ABC transporter proteins, antibiotic synthesis, flagellar assembly, cellulase-related pathways and proteins were significantly up-regulated in the MC treatment compared to the CB treatment, and lactate metabolism was inhibited. In addition, MC was used as a certain carbon source to improve bacterial inhibition of B. licheniformis, its own disease resistance and to regulate the rumen micro-environment. In conclusion, our research provides a potential new probiotic for feed research and a theoretical basis for investigating the mechanisms by which bacteria respond to different carbon sources.

2024-01-26 | PXD042310 | Pride

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