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Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors (FH-A11KRASG12V-TCR) in Treating Patients With Metastatic Pancreatic, Colorectal and Non-Small Cell Lung Cancers With KRAS G12V Mutations

ABSTRACT: This phase I trial studies the side effects and best dose of autologous CD8+ and CD4+ transgenic T cells expressing high affinity KRAS G12V mutation-specific T cell receptors (FH-A11KRASG12V-TCR) and to see how well they work in treating patients with pancreatic, colorectal, and non-small cell lung cancers that has spread from where it first started (primary site) to other places in the body (metastatic). T cells are infection fighting blood cells that can kill tumor cells. The T cells given in this study will come from the patient and will have a new gene put in them that makes them able to recognize KRAS G12V, a protein on the surface of tumor cells. These KRAS G12V-specific T cells may help the body’s immune system identify and kill KRAS G12V pancreatic, colorectal, and non-small cell lung cancers’ tumor cells.

DISEASE(S): Adenocarcinoma,Metastatic Colorectal Adenocarcinoma,Stage Iv Colorectal Cancer Ajcc V8,Carcinoma, Non-small-cell Lung,Stage Iv Pancreatic Cancer Ajcc V8,Stage Iv Lung Cancer Ajcc V8,Lung Neoplasms,Metastatic Lung Non-small Cell Carcinoma,Metastatic Pancreatic Adenocarcinoma

PROVIDER: 92453 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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