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Carbon Nanoparticle-Loaded Iron [CNSI-Fe(II)] in the Treatment of Advanced Solid Tumor

ABSTRACT: This Phase I clinical trial aims to evaluate the safety, tolerability, pharmacokinetics (PK) profile and preliminary efficacy of intratumoral injection of Carbon Nanoparticle-Loaded Iron [CNSI-Fe(II)] in patients with advanced solid tumors. The study also aims to observe dose-limiting toxicities (DLT) of CNSI-Fe(II) to determine the maximum tolerated dose (MTD) or the highest injectable dose in humans, providing dosing guidelines for future clinical studies. CNSI-Fe(II) shows promise as an innovative tumor therapeutic agent due to its unique properties of ferroptosis. The study primarily focuses on assessing the potential efficacy of CNSI-Fe(II) in patients with advanced solid tumors, particularly in patients with Kras mutation, e.g., pancreatic cancer patients.

DISEASE(S): Vulvar Neoplasms,Ovarian Cancer,Pancreas Cancer,Lung Cancer,Cervical Cancer,Thyroid Cancer,Colorectal Cancer,Advanced Solid Tumor,Vulva Cancer,Pancreatic Neoplasms,Breast Cancer

PROVIDER: 92811 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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