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Neuroblastoma Data Access Committee

ABSTRACT: Data Access Committee EGAC00001000085

PROVIDER: EGAC00001000085 | EGA |

REPOSITORIES: EGA

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Publications

Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma.

Sausen Mark M Leary Rebecca J RJ Jones Siân S Wu Jian J Reynolds C Patrick CP Liu Xueyuan X Blackford Amanda A Parmigiani Giovanni G Diaz Luis A LA Papadopoulos Nickolas N Vogelstein Bert B Kinzler Kenneth W KW Velculescu Victor E VE Hogarty Michael D MD

Nature genetics 20121202 1

Neuroblastomas are tumors of peripheral sympathetic neurons and are the most common solid tumor in children. To determine the genetic basis for neuroblastoma, we performed whole-genome sequencing (6 cases), exome sequencing (16 cases), genome-wide rearrangement analyses (32 cases) and targeted analyses of specific genomic loci (40 cases) using massively parallel sequencing. On average, each tumor had 19 somatic alterations in coding genes (range of 3-70). Among genes not previously known to be i ...[more]

PMID: 23202128

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