Genomics

Dataset Information

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ICR DIPG Data Access Committee

ABSTRACT: Data Access Committee EGAC00001000148

PROVIDER: EGAC00001000148 | EGA |

REPOSITORIES: EGA

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Publications

Diffuse intrinsic pontine gliomas (DIPGs) are highly infiltrative malignant glial neoplasms of the ventral pons that, due to their location within the brain, are unsuitable for surgical resection and consequently have a universally dismal clinical outcome. The median survival time is 9-12 months, with neither chemotherapeutic nor targeted agents showing substantial survival benefit in clinical trials in children with these tumors. We report the identification of recurrent activating mutations in  ...[more]

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