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Unige T21

ABSTRACT: Data Access Committee EGAC00001000269

PROVIDER: EGAC00001000269 | EGA |

REPOSITORIES: EGA

ACCESS DATA

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Publications

Biased allelic expression in human primary fibroblast single cells.

Borel Christelle C Ferreira Pedro G PG Santoni Federico F Delaneau Olivier O Fort Alexandre A Popadin Konstantin Y KY Garieri Marco M Falconnet Emilie E Ribaux Pascale P Guipponi Michel M Padioleau Ismael I Carninci Piero P Dermitzakis Emmanouil T ET Antonarakis Stylianos E SE

American journal of human genetics 20141231 1

The study of gene expression in mammalian single cells via genomic technologies now provides the possibility to investigate the patterns of allelic gene expression. We used single-cell RNA sequencing to detect the allele-specific mRNA level in 203 single human primary fibroblasts over 133,633 unique heterozygous single-nucleotide variants (hetSNVs). We observed that at the snapshot of analyses, each cell contained mostly transcripts from one allele from the majority of genes; indeed, 76.4% of th ...[more]

PMID: 25557783

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