TRACERx renal DAC
Ontology highlight
ABSTRACT:
PROVIDER: EGAC00001001907 | EGA |
REPOSITORIES: EGA
Publications
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing.
Gerlinger Marco M Horswell Stuart S Larkin James J Rowan Andrew J AJ Salm Max P MP Varela Ignacio I Fisher Rosalie R McGranahan Nicholas N Matthews Nicholas N Santos Claudio R CR Martinez Pierre P Phillimore Benjamin B Begum Sharmin S Rabinowitz Adam A Spencer-Dene Bradley B Gulati Sakshi S Bates Paul A PA Stamp Gordon G Pickering Lisa L Gore Martin M Nicol David L DL Hazell Steven S Futreal P Andrew PA Stewart Aengus A Swanton Charles C
Nature genetics 20140202 3
Clear cell renal carcinomas (ccRCCs) can display intratumor heterogeneity (ITH). We applied multiregion exome sequencing (M-seq) to resolve the genetic architecture and evolutionary histories of ten ccRCCs. Ultra-deep sequencing identified ITH in all cases. We found that 73-75% of identified ccRCC driver aberrations were subclonal, confounding estimates of driver mutation prevalence. ITH increased with the number of biopsies analyzed, without evidence of saturation in most tumors. Chromosome 3p ...[more]
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