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ABSTRACT: Aggregate results from a case-control study on stroke and ischemic stroke.

PROVIDER: EGAD00000000029 | EGA |

REPOSITORIES: EGA

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Genomewide association studies of stroke.

Ikram M Arfan MA Seshadri Sudha S Bis Joshua C JC Fornage Myriam M DeStefano Anita L AL Aulchenko Yurii S YS Debette Stephanie S Lumley Thomas T Folsom Aaron R AR van den Herik Evita G EG Bos Michiel J MJ Beiser Alexa A Cushman Mary M Launer Lenore J LJ Shahar Eyal E Struchalin Maksim M Du Yangchun Y Glazer Nicole L NL Rosamond Wayne D WD Rivadeneira Fernando F Kelly-Hayes Margaret M Lopez Oscar L OL Coresh Josef J Hofman Albert A DeCarli Charles C Heckbert Susan R SR Koudstaal Peter J PJ Yang Qiong Q Smith Nicholas L NL Kase Carlos S CS Rice Kenneth K Haritunians Talin T Roks Gerwin G de Kort Paul L M PL Taylor Kent D KD de Lau Lonneke M LM Oostra Ben A BA Uitterlinden Andre G AG Rotter Jerome I JI Boerwinkle Eric E Psaty Bruce M BM Mosley Thomas H TH van Duijn Cornelia M CM Breteler Monique M B MM Longstreth W T WT Wolf Philip A PA

The New England journal of medicine 20090415 17

<h4>Background</h4>The genes underlying the risk of stroke in the general population remain undetermined.<h4>Methods</h4>We carried out an analysis of genomewide association data generated from four large cohorts composing the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, including 19,602 white persons (mean [+/-SD] age, 63+/-8 years) in whom 1544 incident strokes (1164 ischemic strokes) developed over an average follow-up of 11 years. We tested the markers most strong ...[more]

PMID: 19369658

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Gene expression analysis of peripheral whole blood RNA following ischemic stroke

Project description:The purpose of this project was to elucidate gene expression in the peripheral whole blood of acute ischemic stroke patients to identify a panel of genes for the diagnosis of acute ischemic stroke. Peripheral blood samples were collected in Paxgene Blood RNA tubes from stroke patients who were >18 years of age with MRI diagnosed ischemic stroke and controls who were non-stroke neurologically healthy. The results suggest a panel of genes can be used to diagnose ischemic stroke, and provide information about the biological pathways involved in the response to acute ischemic stroke in humans. Total RNA extracted from whole blood in n=39 ischemic stroke patients compared to n=24 healthy control subjects.

2010-06-08 | E-GEOD-16561 | biostudies-arrayexpress

The age and genomic integrity of neurons after cortical stroke in humans

Project description:It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA-rearrangements in the human neocortex. We show here that neither is the case, using immunohistochemistry, transcriptome-, genome- and ploidy-analyses, and determination of nuclear bomb test-derived 14C-concentration in neuronal DNA. A large proportion of cortical neurons display DNA-fragmentation and DNA-repair short time after stroke, whereas neurons at chronic stages after stroke show DNA-integrity, demonstrating the relevance of an intact genome for survival. Analyze of potential fusion transcripts in 13 samples, seven cortical ischemic stroke tissue and six control cortex, by deep sequencing using Illumina HiSeq 2000

2014-03-28 | E-GEOD-56267 | biostudies-arrayexpress

Screening for differentially expressed circRNAs in ischemic stroke by RNA sequencing

Project description:Background: Ischemic stroke is a disease with high rate of death and disability worldwide. This study investigated key circRNAs related to ischemic stroke. Methods: Three ischemic stroke patients and three healthy individuals were included in the current study to obtain the circRNA expression profiles by RNA sequencing. Through bioinformatic analysis, differentially expressed circRNAs (DEcircRNAs) were identified, and GO and pathway analyses for the host genes of DEcircRNAs were conducted. To further explore the functions of key circRNAs, a DEcircRNA-miRNA interaction network was constructed. Finally, the expression levels of selected circRNAs were validated with qRT-PCR. Results: A total of 736 DEcircRNAs were detected in ischemic stroke. Functional annotation of host genes of DEcircRNAs revealed several significantly enriched pathways, including Fc epsilon RI signaling pathway, B cell receptor signaling pathway, and T cell receptor signaling pathway. A circRNA-miRNA network, including 1544 circRNA-miRNA pairs, 456 circRNAs and 4 miRNAs, was obtained. The qRT-PCR results were largely in keeping with our RNA-seq data. Conclusion: The results of our study may help to elucidate the specific mechanism underlying ischemic stroke.

2021-06-24 | GSE178764 | GEO

Homo sapiens

Project description:Ischemic Stroke Genetics Study (ISGS)

| PRJNA75379 | ENA

Ischemic Stroke Genetics Study (ISGS)

Project description:Ischemic Stroke Genetics Study (ISGS)

| PRJNA75377 | ENA

Gene expression analysis of peripheral whole blood RNA following ischemic stroke

2010-06-01 | GSE16561 | GEO

Ischemic stroke in a Swedish case-control study.

Project description:Background. Genetic risk scores (GRS), summing up the total effect of several single nucleotide polymorphisms (SNPs) in genes associated with either coronary risk or cardiovascular risk factors, have been tested for association with ischemic stroke with conflicting results. Recently an association was found between a GRS, based on 29 SNPs discovered by genome-wide association studies (GWAS) and hypertension. The aim of our study was to investigate the possible association of the same GRS with ischemic stroke on top of other “traditional risk factors”, also testing its potential improvement in indices of discrimination and reclassification, in a Swedish case-control study. Methods and results. Twenty-nine SNPs were genotyped in 3,677 stroke cases and 2,415 controls included in the Lund Stroke Register (LSR), the Malmö Diet and Cancer (MDC) study and the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS). The analysis was conducted in the entire material, and separately for the three samples. After adjustment for hypertension, diabetes mellitus and smoking habits, the GRS was associated with ischemic stroke in the entire material [OR (95% CI) 1.086 (1.029-1.147) per SD increase in the GRS p=0.003] with similar trends in all three samples; LSR [1.050 (0.967-1.140)]; p=0.25], MDC [1.168 (1.060-1.288); p=0.002] and SAHLSIS [1.124 (0.997-1.267); P=0.055]. Measures of discrimination and reclassification improved marginally using the GRS. Conclusions. A blood pressure GRS is independently associated with ischemic stroke risk in three Swedish case-control studies, however, the effect size is low and adds marginally to prediction of stroke on top of traditional risk factors including hypertension.

| EGAS00001000936 | EGA

Dynamic astrocytic gene expression profiles after ischemic stroke

Project description:Analysis of astrocytic gene expression profiles after ischemic stroke. Stroke is a complicated disease caused by the interaction of multiple celltypes. Results provide new insights into the molecular mechanisms underlying astrocytic activation after ischemic stroke.

2024-05-23 | GSE238125 | GEO

Dynamic microglial gene expression profiles after ischemic stroke

Project description:Analysis of microglial gene expression profiles after ischemic stroke. Stroke is a complicated disease caused by the interaction of multiple celltypes. Results provide new insights into the molecular mechanisms underlying microglial activation after ischemic stroke.

2022-01-01 | GSE172456 | GEO

The effect of XUESAITONG on gene expression profile after focal cerebral ischemia in rats

Project description:Xuesaitong injection (XST), a standardized patent Chinese medicine of Panax notoginseng roots (Sanqi in Chinese), has long been used for effective prevention and treatment of stroke in China. However, the mechanisms underlying its effects against ischemic stroke are still poorly understood. In this study, we focused on the polypharmacology of XST against ischemic stroke with a XST-regulated stroke network analysis. Male Sprague Dawley rat model of MCAO and reperfusion were administered XST for 7 days while the control group was not treated.

2014-09-23 | GSE61616 | GEO

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