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Ena-DATASET-PICR-17-03-2014-12:03:29:405-517 - samples

ABSTRACT: Whole exome sequencing of 41 melanomas and normal DNA from Braf mutant mice: 15 tumours from UV exposed mice, 15 tumours from non-exposed mice and 11 from UV exposed, sunscreen-protected mice.

PROVIDER: EGAD00001000775 | EGA |

REPOSITORIES: EGA

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Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53.

Viros Amaya A Sanchez-Laorden Berta B Pedersen Malin M Furney Simon J SJ Rae Joel J Hogan Kate K Ejiama Sarah S Girotti Maria Romina MR Cook Martin M Dhomen Nathalie N Marais Richard R

Nature 20140611 7510

Cutaneous melanoma is epidemiologically linked to ultraviolet radiation (UVR), but the molecular mechanisms by which UVR drives melanomagenesis remain unclear. The most common somatic mutation in melanoma is a V600E substitution in BRAF, which is an early event. To investigate how UVR accelerates oncogenic BRAF-driven melanomagenesis, we used a BRAF(V600E) mouse model. In mice expressing BRAF(V600E) in their melanocytes, a single dose of UVR that mimicked mild sunburn in humans induced clonal ex ...[more]

PMID: 24919155

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