Dataset Information
Ena-DATASET-VUMC-CCA-18-03-2014-11:02:55:717-600 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001000780 | EGA |
REPOSITORIES: EGA
Publications
DNA copy number analysis of fresh and formalin-fixed specimens by shallow whole-genome sequencing with identification and exclusion of problematic regions in the genome assembly.
Genome research 20140918 12
Detection of DNA copy number aberrations by shallow whole-genome sequencing (WGS) faces many challenges, including lack of completion and errors in the human reference genome, repetitive sequences, polymorphisms, variable sample quality, and biases in the sequencing procedures. Formalin-fixed paraffin-embedded (FFPE) archival material, the analysis of which is important for studies of cancer, presents particular analytical difficulties due to degradation of the DNA and frequent lack of matched r ...[more]
