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Icgc-liri-jp_lcb - samples

ABSTRACT: RIKEN collection WGS reads for 61 liver cancer and matched blood samples from 30 donors displaying biliary phenotype

PROVIDER: EGAD00001000809 | EGA |

REPOSITORIES: EGA

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Diverse modes of genomic alteration in hepatocellular carcinoma.

Jhunjhunwala Suchit S Jiang Zhaoshi Z Stawiski Eric W EW Gnad Florian F Liu Jinfeng J Mayba Oleg O Du Pan P Diao Jingyu J Johnson Stephanie S Wong Kwong-Fai KF Gao Zhibo Z Li Yingrui Y Wu Thomas D TD Kapadia Sharookh B SB Modrusan Zora Z French Dorothy M DM Luk John M JM Seshagiri Somasekar S Zhang Zemin Z

Genome biology 20140826 8

<h4>Background</h4>Hepatocellular carcinoma (HCC) is a heterogeneous disease with high mortality rate. Recent genomic studies have identified TP53, AXIN1, and CTNNB1 as the most frequently mutated genes. Lower frequency mutations have been reported in ARID1A, ARID2 and JAK1. In addition, hepatitis B virus (HBV) integrations into the human genome have been associated with HCC.<h4>Results</h4>Here, we deep-sequence 42 HCC patients with a combination of whole genome, exome and transcriptome sequenc ...[more]

PMID: 25159915

Publication: 1/2

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