Dataset Information

Ena-DATASET-Genentech-03-04-2014-21:11:45:639-54 - samples

ABSTRACT: Exome-seq, RNA-Seq, SNP array profiling of gastric tumor samples.

PROVIDER: EGAD00001000815 | EGA |

REPOSITORIES: EGA

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Publications

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Liu Jinfeng J McCleland Mark M Stawiski Eric W EW Gnad Florian F Mayba Oleg O Haverty Peter M PM Durinck Steffen S Chen Ying-Jiun YJ Klijn Christiaan C Jhunjhunwala Suchit S Lawrence Michael M Liu Hanbin H Wan Yinan Y Chopra Vivek V Yaylaoglu Murat B MB Yuan Wenlin W Ha Connie C Gilbert Houston N HN Reeder Jens J Pau Gregoire G Stinson Jeremy J Stern Howard M HM Manning Gerard G Wu Thomas D TD Neve Richard M RM de Sauvage Frederic J FJ Modrusan Zora Z Seshagiri Somasekar S Firestein Ron R Zhang Zemin Z

Nature communications 20140508

Gastric cancer is the second leading cause of worldwide cancer mortality, yet the underlying genomic alterations remain poorly understood. Here we perform exome and transcriptome sequencing and SNP array assays to characterize 51 primary gastric tumours and 32 cell lines. Meta-analysis of exome data and previously published data sets reveals 24 significantly mutated genes in microsatellite stable (MSS) tumours and 16 in microsatellite instable (MSI) tumours. Over half the patients in our collect ...[more]

PMID: 24807215

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Project description:BackgroundMidlife women have a higher risk of cardiometabolic disease than younger women, but the lifelong biological/lifestyle factors responsible for this increase are unclear.ObjectivesWe investigated whether pregnancy history is a risk factor for midlife overweight/obesity and evaluated potential hormonal mechanisms.MethodsThe Baltimore Midlife Women's Health Study, a prospective cohort, recruited 772 women aged 45-54 y. Women reported pregnancy characteristics via questionnaires, trained staff measured weight/height to calculate midlife BMI, and serum hormones were assessed by ELISA. Logistic regression models assessed associations of pregnancy history with risk of midlife overweight/obesity and BMI gain since age 18. We additionally explored whether associations differed by menopausal status, and whether midlife hormones mediated relationships of pregnancy history and midlife BMI.ResultsThese premenopausal or perimenopausal women were 66% Caucasian/White and 30% African American/Black, with a median of 2 live births (range: 0-11) and median age at first birth of 27 y (range: 12-46 y). Women with 0 and ?2 live births had lower odds of overweight/obesity than those with 1 birth (OR = 0.47; 95% CI: 0.23, 0.96; P = 0.04, and OR = 0.58; 95% CI: 0.35, 0.95; P = 0.03, respectively). Women with ?2 live births also had lower odds of BMI gain than those with 1 birth (OR = 0.66; 95% CI: 0.41, 1.06; P = 0.08). Furthermore, women who were older at their first birth had lower odds of overweight/obesity (OR = 0.96; 95% CI: 0.92, 1.00; P = 0.03) and BMI gain (OR = 0.97; 95% CI: 0.93, 1.00; P = 0.06). Number of pregnancies and age at last pregnancy were not associated with midlife overweight/obesity or BMI gain. Associations did not differ by menopausal status and were not explained by midlife hormones.ConclusionsEarlier childbirth and having 1 child increased women's risk of midlife overweight/obesity and BMI gain since age 18. Additional studies should focus on women's childbearing years as a critical determinant of midlife metabolic health.

Dataset Information

Ena-DATASET-Genentech-03-04-2014-21:11:45:639-54 - samples

Publications

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Similar Datasets

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