Dataset Information

Ena-DATASET-DUKE-NUS-15-10-2014-08:01:00:925-302 - samples

ABSTRACT: Description not provided

PROVIDER: EGAD00001001036 | EGA |

REPOSITORIES: EGA

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Publications

Mutation signatures implicate aristolochic acid in bladder cancer development.

Poon Song Ling SL Huang Mi Ni MN Choo Yang Y McPherson John R JR Yu Willie W Heng Hong Lee HL Gan Anna A Myint Swe Swe SS Siew Ee Yan EY Ler Lian Dee LD Ng Lay Guat LG Weng Wen-Hui WH Chuang Cheng-Keng CK Yuen John Sp JS Pang See-Tong ST Tan Patrick P Teh Bin Tean BT Rozen Steven G SG

Genome medicine 20150428 1

<h4>Background</h4>Aristolochic acid (AA) is a natural compound found in many plants of the Aristolochia genus, and these plants are widely used in traditional medicines for numerous conditions and for weight loss. Previous work has connected AA-mutagenesis to upper-tract urothelial cell carcinomas and hepatocellular carcinomas. We hypothesize that AA may also contribute to bladder cancer.<h4>Methods</h4>Here, we investigated the involvement of AA-mutagenesis in bladder cancer by sequencing blad ...[more]

PMID: 26015808

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Project description:BACKGROUND:Participation in lacrosse has grown at the collegiate levels. However, little research has examined the epidemiology of collegiate men's lacrosse injuries. This study describes the epidemiology of injuries in National Collegiate Athletic Association (NCAA) men's lacrosse during the 2009/10-2014/15 academic years. METHODS:Twenty-five men's lacrosse programs provided 63 team-seasons of data for the NCAA Injury Surveillance Program (NCAA-ISP) during the 2009/10-2014/15 academic years. Injuries occurred from participation in an NCAA-sanctioned practice or competition, and required attention from an AT or physician. Injuries were further classified as time loss (TL) injuries if the injury restricted participation for at least 24 h. Injuries were reported through electronic medical record application used by the team medical staff throughout the academic year. Injury rates per 1000 athlete-exposures (AE), injury rate ratios (RR), 95% confidence intervals (CI), and injury proportions were reported. RESULTS:Overall, 1055 men's lacrosse injuries were reported, leading to an injury rate of 5.29/1000AE; 95%CI: 4.98-5.61. The TL injury rate was 2.74/1000AE (95%CI: 2.51-2.96). The overall injury rate was higher in competition than practice (12.35 vs. 3.90/1000AE; RR?=?3.16; 95%CI: 2.79-3.58). Most injuries were to the lower extremity (58.3%), particularly the ankle (14.1%) in competition and the upper leg (14.3%) in practice. Sprains and strains were the most common diagnoses in both competition (26.9 and 23.7%, respectively) and practice (20.2% and 27.4%, respectively). Most injuries in competitions and practices were due to player contact (32.8 and 17.5%, respectively) and non-contact (29.6 and 40.0%, respectively). CONCLUSIONS:Our estimated injury rates are lower than those from previous college men's lacrosse research. This may be due to increased injury awareness, advances in injury prevention exercise programs, or rule changes. Still, injury prevention can aim to continue reducing the incidence and severity of injury, particularly those sustained in competitions and to the lower extremity.

Dataset Information

Ena-DATASET-DUKE-NUS-15-10-2014-08:01:00:925-302 - samples

Publications

Mutation signatures implicate aristolochic acid in bladder cancer development.

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