Dataset Information

DUKE-NUS

ABSTRACT: Organisation EGAO00000000230

PROVIDER: EGAO00000000230 | EGA |

REPOSITORIES: EGA

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Publications

Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.

Jusakul Apinya A Cutcutache Ioana I Yong Chern Han CH Lim Jing Quan JQ Huang Mi Ni MN Padmanabhan Nisha N Nellore Vishwa V Kongpetch Sarinya S Ng Alvin Wei Tian AWT Ng Ley Moy LM Choo Su Pin SP Myint Swe Swe SS Thanan Raynoo R Nagarajan Sanjanaa S Lim Weng Khong WK Ng Cedric Chuan Young CCY Boot Arnoud A Liu Mo M Ong Choon Kiat CK Rajasegaran Vikneswari V Lie Stefanus S Lim Alvin Soon Tiong AST Lim Tse Hui TH Tan Jing J Loh Jia Liang JL McPherson John R JR Khuntikeo Narong N Bhudhisawasdi Vajaraphongsa V Yongvanit Puangrat P Wongkham Sopit S Totoki Yasushi Y Nakamura Hiromi H Arai Yasuhito Y Yamasaki Satoshi S Chow Pierce Kah-Hoe PK Chung Alexander Yaw Fui AYF Ooi London Lucien Peng Jin LLPJ Lim Kiat Hon KH Dima Simona S Duda Dan G DG Popescu Irinel I Broet Philippe P Hsieh Sen-Yung SY Yu Ming-Chin MC Scarpa Aldo A Lai Jiaming J Luo Di-Xian DX Carvalho André Lopes AL Vettore André Luiz AL Rhee Hyungjin H Park Young Nyun YN Alexandrov Ludmil B LB Gordân Raluca R Rozen Steven G SG Shibata Tatsuhiro T Pairojkul Chawalit C Teh Bin Tean BT Tan Patrick P

Cancer discovery 20170630 10

Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in countries with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries, combining whole-genome (71 cases), targeted/exome, copy-number, gene expression, and DNA methylation information. Integrative clustering defined 4 CCA clusters-fluke-positive CCAs (clusters 1/2) are enriched in <i>ERBB2</i> amplifications and <i>TP53</i> mutations; conversely, fluke-negative CCAs (clusters 3/4) exhibit high copy ...[more]

PMID: 28667006

Publication: 1/2

Dataset Information

DUKE-NUS

Publications

Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.

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