Genomics

Dataset Information

0

Ena-DATASET-DKFZ-IBIOS-24-09-2015-15:15:19:594-451 - samples

ABSTRACT: release_2: ICGC PedBrain: whole genome sequencing

PROVIDER: EGAD00001001625 | EGA |

REPOSITORIES: EGA

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Publications

Dissecting the genomic complexity underlying medulloblastoma.

Jones David T W DT   Jäger Natalie N   Kool Marcel M   Zichner Thomas T   Hutter Barbara B   Sultan Marc M   Cho Yoon-Jae YJ   Pugh Trevor J TJ   Hovestadt Volker V   Stütz Adrian M AM   Rausch Tobias T   Warnatz Hans-Jörg HJ   Ryzhova Marina M   Bender Sebastian S   Sturm Dominik D   Pleier Sabrina S   Cin Huriye H   Pfaff Elke E   Sieber Laura L   Wittmann Andrea A   Remke Marc M   Witt Hendrik H   Hutter Sonja S   Tzaridis Theophilos T   Weischenfeldt Joachim J   Raeder Benjamin B   Avci Meryem M   Amstislavskiy Vyacheslav V   Zapatka Marc M   Weber Ursula D UD   Wang Qi Q   Lasitschka Bärbel B   Bartholomae Cynthia C CC   Schmidt Manfred M   von Kalle Christof C   Ast Volker V   Lawerenz Chris C   Eils Jürgen J   Kabbe Rolf R   Benes Vladimir V   van Sluis Peter P   Koster Jan J   Volckmann Richard R   Shih David D   Betts Matthew J MJ   Russell Robert B RB   Russell Robert B RB   Coco Simona S   Tonini Gian Paolo GP   Schüller Ulrich U   Hans Volkmar V   Graf Norbert N   Kim Yoo-Jin YJ   Monoranu Camelia C   Roggendorf Wolfgang W   Unterberg Andreas A   Herold-Mende Christel C   Milde Till T   Kulozik Andreas E AE   von Deimling Andreas A   Witt Olaf O   Maass Eberhard E   Rössler Jochen J   Ebinger Martin M   Schuhmann Martin U MU   Frühwald Michael C MC   Hasselblatt Martin M   Jabado Nada N   Rutkowski Stefan S   von Bueren André O AO   Williamson Dan D   Clifford Steven C SC   McCabe Martin G MG   Collins V Peter VP   Wolf Stephan S   Wiemann Stefan S   Lehrach Hans H   Brors Benedikt B   Scheurlen Wolfram W   Felsberg Jörg J   Reifenberger Guido G   Northcott Paul A PA   Taylor Michael D MD   Meyerson Matthew M   Pomeroy Scott L SL   Yaspo Marie-Laure ML   Korbel Jan O JO   Korshunov Andrey A   Eils Roland R   Pfister Stefan M SM   Lichter Peter P  

Nature 20120801 7409

Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain stem. It is the most common malignant brain tumour in children, and shows tremendous biological and clinical heterogeneity. Despite recent treatment advances, approximately 40% of children experience tumour recurrence, and 30% will die from their disease. Those who survive often have a significantly reduced quality of life. Four tumour subgroups with distinct clinical, biological and genetic profiles ar  ...[more]

PMID: 22832583

Publication: 1/2

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