Project description:Paediatric glioblastoma (pedGBM) is characterised by substantial intertumoural heterogeneity. In order to identify the genetic lesions underlying tumourigenesis, we analysed whole genomes and transcriptomes of pedGBMs and in vitro model systems by next generation sequencing. Novel fusions of the receptor tyrosine kinase MET lead us to investigate targeted therapy using MET inhibitors. This study is part of the International Cancer Genome Consortium PedBrain Tumor Project (ICGC PedBrain, http://www.pedbraintumor.org/).

| EGAS00001001139 | EGA

ena-DATASET-DKFZ-IBIOS-25-01-2016-08:42:37:641-84 - samples

Project description:Whole genome bisulfite sequencing of pedbrain - medulloblastoma

| EGAD00001001891 | EGA

Transcription profiling of human paediatric glioblastoma cells treated with insulin-like growth factor 1 receptor inhibitors

Project description:We have previously determined the insulin-like growth factor 1 receptor (IGF1R) to be amplified and overexpressed in paediatric glioblastoma. In order to probe the efficacy and mechanisms of action of various inhibitors of the receptor, we have carried out expression profiling of paediatric glioblastoma cells treated with 5x IC50 of the compounds PPP and NVP-AEW541 over a 24 hour time-course.

2011-01-08 | E-TABM-889 | biostudies-arrayexpress