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Ena-DATASET-KAIST-16-12-2016-08:57:12:493-50 - samples

ABSTRACT: In this study, we sequenced three NUT midline carcinoma genomes and their transcriptomes (NMC1, NMC2 and Ty-82), and two paired normal blood samples (for NMC1 and NMC2). Whole-genome sequencing libraries were generated by PCR-free methods, and sequencing run was made in HiSeq X machines. Transcriptome (mRNA) sequencing was performed in HiSeq 2500 machines. PCR duplicates-marked, indel-realigned, and base-recalibrarted BAM files are provided in our dataset.

PROVIDER: EGAD00001003117 | EGA |

REPOSITORIES: EGA

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Complex chromosomal rearrangements by single catastrophic pathogenesis in NUT midline carcinoma.

Lee J-K JK Louzada S S An Y Y Kim S Y SY Kim S S Youk J J Park S S Koo S H SH Keam B B Jeon Y K YK Ku J-L JL Yang F F Kim T M TM Ju Y S YS

Annals of oncology : official journal of the European Society for Medical Oncology 20170401 4

<h4>Background</h4>Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare aggressive malignancy often occurring in the tissues of midline anatomical structures. Except for the pathognomonic BRD3/4-NUT rearrangement, the comprehensive landscape of genomic alterations in NMCs has been unexplored.<h4>Patients and methods</h4>We investigated three NMC cases, including two newly diagnosed NMC patients in Seoul National University Hospital, and a previously reported cell line (Ty-82). Whole ...[more]

PMID: 28203693

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