Project description:Bullous pemphigoid (BP) is the most common autoimmune skin blistering disease characterized by autoimmunity against the hemidesmosomal proteins BP180, type XVII collagen, and BP230. To elucidate the genetic basis of susceptibility to BP, we performed the first genome-wide association study (GWAS) in Germans. This GWAS was combined with HLA locus targeted sequencing in an additional independent BP cohort. The strongest association with BP in Germans tested in this study was observed in the two HLA loci, HLA-DQA1*05:05 and HLA-DRB1*07:01. Further studies with increased sample sizes and complex studies integrating multiple pathogenic drivers will be conducted.

| S-EPMC8136166 | biostudies-literature

ena-DATASET-KNIH-31-07-2017-05:29:57:796-1200 - samples

Project description:A IPS05_X_NPC_WGBS paired end data for Neural progenitor cells(Nestin)

| EGAD00001003477 | EGA

ena-DATASET-KNIH-31-07-2017-05:49:12:857-1222 - samples

Project description:A CKD25_C_Podo_smRNA-Seq single end data for Podocytes(CD90(-) Podocalyxin(+), kidney)

| EGAD00001003499 | EGA

ena-DATASET-KNIH-31-07-2017-05:31:32:352-1202 - samples

Project description:A OB56_N_PreA_WGBS paired end data for Preadipocytes(fat)

| EGAD00001003479 | EGA

ena-DATASET-KNIH-31-07-2017-05:36:31:342-1206 - samples

Project description:A CKD25_C_Podo_mRNA-Seq paired end data for Podocytes(CD90(-) Podocalyxin(+), kidney)