Project description:Bullous pemphigoid (BP) is the most common autoimmune skin blistering disease characterized by autoimmunity against the hemidesmosomal proteins BP180, type XVII collagen, and BP230. To elucidate the genetic basis of susceptibility to BP, we performed the first genome-wide association study (GWAS) in Germans. This GWAS was combined with HLA locus targeted sequencing in an additional independent BP cohort. The strongest association with BP in Germans tested in this study was observed in the two HLA loci, HLA-DQA1*05:05 and HLA-DRB1*07:01. Further studies with increased sample sizes and complex studies integrating multiple pathogenic drivers will be conducted.

| S-EPMC8136166 | biostudies-literature

ena-DATASET-KNIH-31-07-2017-05:52:51:642-1228 - samples

Project description:A IPS05_X_NPC_smRNA-Seq single end data for Neural progenitor cells(Nestin)

| EGAD00001003505 | EGA

ena-DATASET-KNIH-31-07-2017-05:35:52:222-1205 - samples

Project description:A CKD24_C_Podo_mRNA-Seq paired end data for Podocytes(CD90(-) Podocalyxin(+), kidney)

| EGAD00001003482 | EGA

ena-DATASET-KNIH-31-07-2017-05:14:39:239-1191 - samples

Project description:A CKD23_C_Mesan_WGBS paired end data for Mesangial cells(kidney)

| EGAD00001003468 | EGA

HLA-C*05:01 and HLA-C*07:02 from 721.221 cells

Project description:HLA-C expresion varies widely across the different HLA-C alleles. MicroRNA binding can partly explain the differences in HLA-C allele expression however other contributing factors still remain undetermined. Here we use two common HLA-C alleles, HLA-C*05:01 and HLA-C*07:02, to explore differences in expression levels. Using functional, structural and peptide repertoire comparisons we demonstrate that HLA-C expression levels are not only modulated at the RNA level but also at the protein level. This dataset contains RAW data and database search results for HLA-C*05:01 and HLA-C*07:02 from the 721.221 cell line.

2017-07-03 | PXD006455 | Pride

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