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C206f97a-4770-4337-a7bd-0bf63eede603 - samples

ABSTRACT: Whole-exome sequencing dataset for the Australian Ovarian Cancer Study (AOCS) and The Jikei University School of Medicine (JIKEI) ovarian clear cell carcinoma (OCCC) clinical outliers project, representing 10 donors. Consists of 20 fastq files: one normal and one tumour from each patient.

PROVIDER: EGAD00001006004 | EGA |

REPOSITORIES: EGA

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Survival Following Chemotherapy in Ovarian Clear Cell Carcinoma Is Not Associated with Pathological Misclassification of Tumor Histotype.

Takenaka Masataka M Köbel Martin M Garsed Dale W DW Fereday Sian S Pandey Ahwan A Etemadmoghadam Dariush D Hendley Joy J Kawabata Ayako A Noguchi Daito D Yanaihara Nozomu N Takahashi Hiroyuki H Kiyokawa Takako T Ikegami Masahiro M Takano Hirokuni H Isonishi Seiji S Ochiai Kazuhiko K Traficante Nadia N Gadipally Sreeja S Semple Timothy T Vassiliadis Dane D Amarasinghe Kausyalya K Li Jason J Mir Arnau Gisela G Okamoto Aikou A Friedlander Michael M Bowtell David D L DDL

Clinical cancer research : an official journal of the American Association for Cancer Research 20190409 13

<h4>Purpose</h4>Although ovarian clear cell carcinomas (OCCC) are commonly resistant to platinum-based chemotherapy, good clinical outcomes are observed in a subset of patients. The explanation for this is unknown but may be due to misclassification of high-grade serous ovarian cancer (HGSOC) as OCCC or mixed histology.<h4>Experimental design</h4>To discover potential biomarkers of survival benefit following platinum-based chemotherapy, we ascertained a cohort of 68 Japanese and Australian patie ...[more]

PMID: 30967419

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