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Merged_dataset - samples

ABSTRACT: This dataset contains merged data from the 22 Hodgkin lymphoma and 5 reactive lymph node samples, including count data and cell cluster assignments.

PROVIDER: EGAD00001006221 | EGA |

REPOSITORIES: EGA

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Single-Cell Transcriptome Analysis Reveals Disease-Defining T-cell Subsets in the Tumor Microenvironment of Classic Hodgkin Lymphoma.

Aoki Tomohiro T Chong Lauren C LC Takata Katsuyoshi K Milne Katy K Hav Monirath M Colombo Anthony A Chavez Elizabeth A EA Nissen Michael M Wang Xuehai X Miyata-Takata Tomoko T Lam Vivian V Viganò Elena E Woolcock Bruce W BW Telenius Adèle A Li Michael Y MY Healy Shannon S Ghesquiere Chanel C Kos Daniel D Goodyear Talia T Veldman Johanna J Zhang Allen W AW Kim Jubin J Saberi Saeed S Ding Jiarui J Farinha Pedro P Weng Andrew P AP Savage Kerry J KJ Scott David W DW Krystal Gerald G Nelson Brad H BH Mottok Anja A Merchant Akil A Shah Sohrab P SP Steidl Christian C

Cancer discovery 20191219 3

Hodgkin lymphoma is characterized by an extensively dominant tumor microenvironment (TME) composed of different types of noncancerous immune cells with rare malignant cells. Characterization of the cellular components and their spatial relationship is crucial to understanding cross-talk and therapeutic targeting in the TME. We performed single-cell RNA sequencing of more than 127,000 cells from 22 Hodgkin lymphoma tissue specimens and 5 reactive lymph nodes, profiling for the first time the phen ...[more]

PMID: 31857391

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