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Ena-DATASET-DCPTCUHK-07-06-2021-04:30:41:771-719 - samples

ABSTRACT: The dataset contains 2x75bp paired-end sequencing data in DNASE1L3-deficient human subjects. We performed bisulfite sequencing of plasma samples from three DNASE1L3-deficient subjects and one heterozygous parent to investigate how nuclease deficiencies alter plasma cell-free DNA methylation profiles.

PROVIDER: EGAD00001007750 | EGA |

REPOSITORIES: EGA

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ena-DATASET-DCPTCUHK-07-06-2021-04:58:11:091-720 - samples

Project description:The dataset contains sequencing data in wildtype, Dnase1-deficient and Dnase1l3-deficient mice. We performed 2 x 75bp paired-end whole genome bisulfite sequencing of pooled plasma cell-free DNA (cfDNA) and buffy coat genomic DNA. The effects of DNASE1L3 or DNASE1 deficiency on cfDNA methylation was explored in plasma of mice deficient in these nucleases.

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