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EGAS00001003774-sc-2024-04-29T09:26:55Z - samples

ABSTRACT: Colorectal cancer Ã¢Â€Â“ unmapped reads (Mutographs)

PROVIDER: EGAD00001015364 | EGA |

REPOSITORIES: EGA

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Quantitative and dynamic catalogs of proteins released during apoptotic and necroptotic cell death

Project description:The inflammatory functions of the cytokine tumor necrosis factor (TNF) rely on its ability to induce cytokine production and to induce cell death. Caspase dependent and independent pathways Ã¢â‚¬â€œ apoptosis and necroptosis Ã¢â‚¬â€œ respectively, regulate immunogenicity by the release of distinct sets of cellular proteins. To obtain an unbiased, systems-level understanding of this important process, we here applied mass spectrometry-based proteomics to dissect protein release during apoptosis and necroptosis. We report hundreds of proteins released from human myeloid cells in time-course experiments. Both cell death types induce receptor shedding, but only apoptotic cells released nucleosome components. Conversely, necroptotic cells release lysosomal components by activating lysosomal exocytosis at early stages of necroptosis- induced membrane permeabilisation and show reduced release of conventionally secreted cytokines.

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An automated and fast sample preparation workflow for laser microdissection guided ultrasensitive proteomics

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2024-03-22 | PXD047762 | Pride

EGAS00001003542-sc-2023-10-10T14:42:07Z - samples

Project description:Geographic variation of mutagenic exposures in kidney cancer genomes Ã¢Â€Â“ sequence data (Mutographs)

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EGAS00001003542-sc-2023-10-16T09:05:13Z - samples

Project description:Geographic variation of mutagenic exposures in kidney cancer genomes Ã¢Â€Â“ patient metadata files (Mutographs)

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EGAS00001003542-sc-2023-10-16T08:57:08Z - samples

Project description:Geographic variation of mutagenic exposures in kidney cancer genomes Ã¢Â€Â“ filtered vcf files (Mutographs)

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EGAS00001003542-sc-2023-11-02T13:55:33Z - samples

Project description:Geographic variation of mutagenic exposures in kidney cancer genomes Ã¢Â€Â“ copy number variants (Mutographs)

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EGAS00001003542-sc-2023-11-02T13:59:23Z - samples

Project description:Geographic variation of mutagenic exposures in kidney cancer genomes Ã¢Â€Â“ structural variation vcf files ( Mutographs )

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EGAS00001003774-sc-2024-11-15T11:56:41Z - samples

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EGAS00001003542-sc-2020-12-08T14:37:12Z - samples

Project description:Mutational signatures in esophageal squamous cell carcinoma from eight countries of varying incidence Ã¢Â€Â“ patient metatdata (Mutographs)

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EGAS00001002725-sc-2021-01-13T09:43:43Z - samples

Project description:Mutational signatures in esophageal squamous cell carcinoma from eight countries of varying incidence Ã¢Â€Â“ sequence data (Mutographs)

| EGAD00001006868 | EGA

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