Ontology highlight
ABSTRACT:
PROVIDER: EGAD00010000276 | EGA |
REPOSITORIES: EGA
Rudin Charles M CM Durinck Steffen S Stawiski Eric W EW Poirier John T JT Modrusan Zora Z Shames David S DS Bergbower Emily A EA Guan Yinghui Y Shin James J Guillory Joseph J Rivers Celina Sanchez CS Foo Catherine K CK Bhatt Deepali D Stinson Jeremy J Gnad Florian F Haverty Peter M PM Gentleman Robert R Chaudhuri Subhra S Janakiraman Vasantharajan V Jaiswal Bijay S BS Parikh Chaitali C Yuan Wenlin W Zhang Zemin Z Koeppen Hartmut H Wu Thomas D TD Stern Howard M HM Yauch Robert L RL Huffman Kenneth E KE Paskulin Diego D DD Illei Peter B PB Varella-Garcia Marileila M Gazdar Adi F AF de Sauvage Frederic J FJ Bourgon Richard R Minna John D JD Brock Malcolm V MV Seshagiri Somasekar S
Nature genetics 20120902 10
Small-cell lung cancer (SCLC) is an exceptionally aggressive disease with poor prognosis. Here, we obtained exome, transcriptome and copy-number alteration data from approximately 53 samples consisting of 36 primary human SCLC and normal tissue pairs and 17 matched SCLC and lymphoblastoid cell lines. We also obtained data for 4 primary tumors and 23 SCLC cell lines. We identified 22 significantly mutated genes in SCLC, including genes encoding kinases, G protein-coupled receptors and chromatin-m ...[more]