Dataset Information
Case_Affymetrix - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00010000514 | EGA |
REPOSITORIES: EGA
Publications
Mutational context and diverse clonal development in early and late bladder cancer.
Cell reports 20140515 5
Bladder cancer (or urothelial cell carcinoma [UCC]) is characterized by field disease (malignant alterations in surrounding mucosa) and frequent recurrences. Whole-genome, exome, and transcriptome sequencing of 38 tumors, including four metachronous tumor pairs and 20 superficial tumors, identified an APOBEC mutational signature in one-third. This was biased toward the sense strand, correlated with mean expression level, and clustered near breakpoints. A>G mutations were up to eight times more f ...[more]