Dataset Information
HELIC_MANOLIS_OmniExpress - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00010000522 | EGA |
REPOSITORIES: EGA
Publications
Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants.
Nature communications 20141106
Isolated populations are emerging as a powerful study design in the search for low-frequency and rare variant associations with complex phenotypes. Here we genotype 2,296 samples from two isolated Greek populations, the Pomak villages (HELIC-Pomak) in the North of Greece and the Mylopotamos villages (HELIC-MANOLIS) in Crete. We compare their genomic characteristics to the general Greek population and establish them as genetic isolates. In the MANOLIS cohort, we observe an enrichment of missense ...[more]
