15x WGS HELIC MANOLIS
Ontology highlight
ABSTRACT:
PROVIDER: EGAS00001001207 | EGA |
REPOSITORIES: EGA
Similar Datasets
Project description:15x whole genome sequencing in samples from the Cretan Greek isolate collection HELIC MANOLIS
| EGAD00001001897 | EGA
Project description:Isolated populations can empower the identification of rare variation associated with complex traits through next generation association studies. Here we have genotyped individuals from a Greek population isolate on the Illumina HumanExome Beadchip. The HELIC (Hellenic Isolated Cohorts) MANOLIS (Minoan Isolates) collection focuses on Anogia and surrounding Mylopotamos villages. Recruitment of this population-based sample was primarily carried out at the village medical centres. All individuals were older than 17 years and had to have at least one parent from the Mylopotamos area. www.helic.org **The data may not be used for population genetics analyses.**
| EGAS00001000630 | EGA
Project description:Whole-genome sequencing at 4x of 250 samples from the Greek isolate
collection HELIC
| EGAD00001001636 | EGA
Project description:Isolated populations can empower the identification of rare variation associated with complex traits through next generation association studies. Here we have genotyped individuals from a Greek population isolate on the Illumina Human OmniExpress BeadChip array. The HELIC (Hellenic Isolated Cohorts) MANOLIS (Minoan Isolates) collection focuses on Anogia and surrounding Mylopotamos villages. Recruitment of this population-based sample was primarily carried out at the village medical centres. All individuals were older than 17 years and had to have at least one parent from the Mylopotamos area. www.helic.org **The data may not be used for population genetics analyses**
| EGAS00001000687 | EGA
Project description:Whole-genome sequencing at 1x of samples from the Cretan Greek isolate collection HELIC-MANOLIS. Genome-wide association studies of complex traits have been successful in identifying common variant associations, but a substantial heritability gap remains. The field of complex trait genetics is shifting towards the study of low frequency and rare variants, which are hypothesised to have larger effects. The study of these variants can be empowered by focusing on isolated populations, in which rare variants may have increased in frequency and linkage disequilibrium tends to be extended. This work focuses on an isolated population from Crete, Greece. Sequencing is very efficient in isolated populations, because variants found in a few samples will be shared by others in extended haplotype contexts, supporting accurate imputation.
| EGAS00001000392 | EGA
Project description:The HELIC study has been whole genome sequencing individuals from 2 Greek isolated
populations at 1x depth. The genotype calling process crucially involves a VQSR step
followed by imputation-based refinement. We have been investigating optimal ways to
increase calling accuracy. To aid us in setting appropriate parameters for VQSR and other
QC steps, we have carried out whole exome sequencing of a small number of
HELIC samples.
| EGAS00001000602 | EGA
Project description:Isolated populations can empower the identification of rare variation associated with complex traits through next generation association studies. Here we have genotyped individuals from a Greek population isolate on the Illumina CoreExome Beadchip. The HELIC (Hellenic Isolated Cohorts) MANOLIS (Minoan Isolates) collection focuses on Anogia and surrounding Mylopotamos villages. Recruitment of this population-based sample was primarily carried out at the village medical centres. All individuals were older than 17 years and had to have at least one parent from the Mylopotamos area. www.helic.org
| EGAS00001000896 | EGA
Project description:Historical "Special Listeria Culture Collection" whole genome sequencing
| PRJEB11656 | ENA
Project description:Whole-genome sequencing at 1x of samples from the Cretan Greek isolate collection HELIC-MANOLIS. Genome-wide association studies of complex traits have been successful in identifying common variant associations, but a substantial heritability gap remains. The field of complex trait genetics is shifting towards the study of low frequency and rare variants, which are hypothesised to have larger effects. The study of these variants can be empowered by focusing on isolated populations, in which rare variants may have increased in frequency and linkage disequilibrium tends to be extended. This work focuses on an isolated population from Crete, Greece. Sequencing is very efficient in isolated populations, because variants found in a few samples will be shared by others in extended haplotype contexts, supporting accurate imputation.
| EGAD00001001637 | EGA