BASIS miRNA data
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00010000917 | EGA |
REPOSITORIES: EGA
Publications
Landscape of somatic mutations in 560 breast cancer whole-genome sequences.
Nik-Zainal Serena S Davies Helen H Staaf Johan J Ramakrishna Manasa M Glodzik Dominik D Zou Xueqing X Martincorena Inigo I Alexandrov Ludmil B LB Martin Sancha S Wedge David C DC Van Loo Peter P Ju Young Seok YS Smid Marcel M Brinkman Arie B AB Morganella Sandro S Aure Miriam R MR Lingjærde Ole Christian OC Langerød Anita A Ringnér Markus M Ahn Sung-Min SM Boyault Sandrine S Brock Jane E JE Broeks Annegien A Butler Adam A Desmedt Christine C Dirix Luc L Dronov Serge S Fatima Aquila A Foekens John A JA Gerstung Moritz M Hooijer Gerrit K J GK Jang Se Jin SJ Jones David R DR Kim Hyung-Yong HY King Tari A TA Krishnamurthy Savitri S Lee Hee Jin HJ Lee Jeong-Yeon JY Li Yilong Y McLaren Stuart S Menzies Andrew A Mustonen Ville V O'Meara Sarah S Pauporté Iris I Pivot Xavier X Purdie Colin A CA Raine Keiran K Ramakrishnan Kamna K Rodríguez-González F Germán FG Romieu Gilles G Sieuwerts Anieta M AM Simpson Peter T PT Shepherd Rebecca R Stebbings Lucy L Stefansson Olafur A OA Teague Jon J Tommasi Stefania S Treilleux Isabelle I Van den Eynden Gert G GG Vermeulen Peter P Vincent-Salomon Anne A Yates Lucy L Caldas Carlos C van't Veer Laura L Tutt Andrew A Knappskog Stian S Tan Benita Kiat Tee BK Jonkers Jos J Borg Åke Å Ueno Naoto T NT Sotiriou Christos C Viari Alain A Futreal P Andrew PA Campbell Peter J PJ Span Paul N PN Van Laere Steven S Lakhani Sunil R SR Eyfjord Jorunn E JE Thompson Alastair M AM Birney Ewan E Stunnenberg Hendrik G HG van de Vijver Marc J MJ Martens John W M JW Børresen-Dale Anne-Lise AL Richardson Andrea L AL Kong Gu G Thomas Gilles G Stratton Michael R MR
Nature 20160502 7605
We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93 protein-coding cancer genes carried probable driver mutations. Some non-coding regions exhibited high mutation frequencies, but most have distinctive structural features probably causing elevated mutation rates and do not contain driver mutations. Mutational signature analysis was extended ...[more]
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