Project description:The present study aimed to investigate differentially expressed genes in whole blood obtained from patients with lumbar disc prolapse and healthy volunteers. A total of 8 patients with lumbar disc prolapse and 8 healthy volunteers were recruited. An Agilent SurePrint G3 human gene expression microarray 8x60 K was used to perform the microarray analyses.
Project description:In this study we analyse a gene expression dataset, obtained by microarray hybridization, consisting of T lymphocytes from 25 healthy male volunteers with ages ranging over whole adult lifespan (25 to 97 years). Large groups of genes exhibiting non-monotonic expression patterns over time were observed, highlighting similarities in gene expression profiles of young and ‘‘successfully aged’’ individuals.
Project description:This clinical trial (NCT02252640) assesses the safety and immune responses to vaccination with experimental malaria vaccine candidates RTS,S/AS01, ChAd63 ME-TRAP and MVA ME-TRAP in different combinations. All healthy volunteers were recruited in England and administered the experimental malaria vaccines. Furthermore, volunteers were infected with malaria by mosquito bites, 12 weeks after the first vaccination to assess vaccine efficacy.
Project description:Using lipopolysaccharide inhalation to induce acute inflammation in healthy volunteers and examine the impact on bronchoalveolar lavage (BAL) fluid and blood MP repertoire. This study defines the characteristics of human DCs and monocytes recruited into bronchoalveolar space immediately following localised acute inflammatory stimulus in vivo.
