Genomics

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BMI EWAS summary stats

ABSTRACT: Summary statistics for a multi-cohort epigenome-wide association study. This includes summary statistics (effect-size, standard error, p-value) for 470,000 methylation markers.

PROVIDER: EGAD00010001029 | EGA |

REPOSITORIES: EGA

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Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.

Wahl Simone S   Drong Alexander A   Lehne Benjamin B   Loh Marie M   Scott William R WR   Kunze Sonja S   Tsai Pei-Chien PC   Ried Janina S JS   Zhang Weihua W   Yang Youwen Y   Tan Sili S   Fiorito Giovanni G   Franke Lude L   Guarrera Simonetta S   Kasela Silva S   Kriebel Jennifer J   Richmond Rebecca C RC   Adamo Marco M   Afzal Uzma U   Ala-Korpela Mika M   Albetti Benedetta B   Ammerpohl Ole O   Apperley Jane F JF   Beekman Marian M   Bertazzi Pier Alberto PA   Black S Lucas SL   Blancher Christine C   Bonder Marc-Jan MJ   Brosch Mario M   Carstensen-Kirberg Maren M   de Craen Anton J M AJ   de Lusignan Simon S   Dehghan Abbas A   Elkalaawy Mohamed M   Fischer Krista K   Franco Oscar H OH   Gaunt Tom R TR   Hampe Jochen J   Hashemi Majid M   Isaacs Aaron A   Jenkinson Andrew A   Jha Sujeet S   Kato Norihiro N   Krogh Vittorio V   Laffan Michael M   Meisinger Christa C   Meitinger Thomas T   Mok Zuan Yu ZY   Motta Valeria V   Ng Hong Kiat HK   Nikolakopoulou Zacharoula Z   Nteliopoulos Georgios G   Panico Salvatore S   Pervjakova Natalia N   Prokisch Holger H   Rathmann Wolfgang W   Roden Michael M   Rota Federica F   Rozario Michelle Ann MA   Sandling Johanna K JK   Schafmayer Clemens C   Schramm Katharina K   Siebert Reiner R   Slagboom P Eline PE   Soininen Pasi P   Stolk Lisette L   Strauch Konstantin K   Tai E-Shyong ES   Tarantini Letizia L   Thorand Barbara B   Tigchelaar Ettje F EF   Tumino Rosario R   Uitterlinden Andre G AG   van Duijn Cornelia C   van Meurs Joyce B J JB   Vineis Paolo P   Wickremasinghe Ananda Rajitha AR   Wijmenga Cisca C   Yang Tsun-Po TP   Yuan Wei W   Zhernakova Alexandra A   Batterham Rachel L RL   Smith George Davey GD   Deloukas Panos P   Heijmans Bastiaan T BT   Herder Christian C   Hofman Albert A   Lindgren Cecilia M CM   Milani Lili L   van der Harst Pim P   Peters Annette A   Illig Thomas T   Relton Caroline L CL   Waldenberger Melanie M   Järvelin Marjo-Riitta MR   Bollati Valentina V   Soong Richie R   Spector Tim D TD   Scott James J   McCarthy Mark I MI   Elliott Paul P   Bell Jordana T JT   Matullo Giuseppe G   Gieger Christian C   Kooner Jaspal S JS   Grallert Harald H   Chambers John C JC  

Nature 20161221 7635

Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of developing type 2 diabetes, cardiovascular disease and related metabolic and inflammatory disturbances. Although the mechanisms linking adiposity to associated clinical conditions are poorly understood, recent studies suggest that adiposity may influence DNA methylation, a key regulator of gene expression and molecular phenotype. Here we use epigenome-wide association to show that body mass index  ...[more]

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