Other

Dataset Information

1K

The Ohio State University Comprehensive Cancer Center


ABSTRACT: Organisation EGAO00000000191

PROVIDER: EGAO00000000191 | EGA |

REPOSITORIES: EGA

altmetric image

Publications


Genomic instability is a hallmark of human cancers, including the 5% caused by human papillomavirus (HPV). Here we report a striking association between HPV integration and adjacent host genomic structural variation in human cancer cell lines and primary tumors. Whole-genome sequencing revealed HPV integrants flanking and bridging extensive host genomic amplifications and rearrangements, including deletions, inversions, and chromosomal translocations. We present a model of "looping" by which HPV  ...[more]

Similar Datasets

| EGAO00000001293 | EGA
| EGAO00000000294 | EGA
| EGAO00000000938 | EGA
| EGAO00000001231 | EGA
| EGAO00000000107 | EGA
| S-EPMC6192009 | biostudies-literature
| EGAO00000000705 | EGA
| S-EPMC3650730 | biostudies-literature
| EGAO00000000396 | EGA
| EGAO00000000943 | EGA