Dataset Information

CRUK-LRI

ABSTRACT: Organisation EGAO00000000203

PROVIDER: EGAO00000000203 | EGA |

REPOSITORIES: EGA

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Publications

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing.

Gerlinger Marco M Horswell Stuart S Larkin James J Rowan Andrew J AJ Salm Max P MP Varela Ignacio I Fisher Rosalie R McGranahan Nicholas N Matthews Nicholas N Santos Claudio R CR Martinez Pierre P Phillimore Benjamin B Begum Sharmin S Rabinowitz Adam A Spencer-Dene Bradley B Gulati Sakshi S Bates Paul A PA Stamp Gordon G Pickering Lisa L Gore Martin M Nicol David L DL Hazell Steven S Futreal P Andrew PA Stewart Aengus A Swanton Charles C

Nature genetics 20140202 3

Clear cell renal carcinomas (ccRCCs) can display intratumor heterogeneity (ITH). We applied multiregion exome sequencing (M-seq) to resolve the genetic architecture and evolutionary histories of ten ccRCCs. Ultra-deep sequencing identified ITH in all cases. We found that 73-75% of identified ccRCC driver aberrations were subclonal, confounding estimates of driver mutation prevalence. ITH increased with the number of biopsies analyzed, without evidence of saturation in most tumors. Chromosome 3p ...[more]

PMID: 24487277

Publication: 1/2

Dataset Information

CRUK-LRI

Publications

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing.

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