Dataset Information
CRUK Cambridge Institute. University if Cambridge
Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000823 | EGA |
REPOSITORIES: EGA
Publications
A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds.
Cell 20160915 1
The inter- and intra-tumor heterogeneity of breast cancer needs to be adequately captured in pre-clinical models. We have created a large collection of breast cancer patient-derived tumor xenografts (PDTXs), in which the morphological and molecular characteristics of the originating tumor are preserved through passaging in the mouse. An integrated platform combining in vivo maintenance of these PDTXs along with short-term cultures of PDTX-derived tumor cells (PDTCs) was optimized. Remarkably, th ...[more]
