Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000350 | EGA |
REPOSITORIES: EGA
Oncotarget 20160401 17
The clinical heterogeneity of prostate cancer (PCa) makes it difficult to identify those patients that could benefit from more aggressive treatments. As a contribution to a better understanding of the genomic changes in the primary tumor that are associated with the development of high-risk disease, we performed exome sequencing and copy number determination of a clinically homogeneous cohort of 47 high-risk PCas. We confirmed recurrent mutations in SPOP, PTEN and TP53 among the 850 point mutati ...[more]