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Omics score: 1000

CeMM Research Centre for Molecular Medicine of the Austrian Academy of Sciences

ABSTRACT: Organisation EGAO00000000754

OTHER RELATED OMICS DATASETS IN: PRJNA321180

PROVIDER: EGAO00000000754 | EGA |

REPOSITORIES: EGA

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Publications

Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks.

Rendeiro André F AF Schmidl Christian C Strefford Jonathan C JC Walewska Renata R Davis Zadie Z Farlik Matthias M Oscier David D Bock Christoph C

Nature communications 20160627

Chronic lymphocytic leukaemia (CLL) is characterized by substantial clinical heterogeneity, despite relatively few genetic alterations. To provide a basis for studying epigenome deregulation in CLL, here we present genome-wide chromatin accessibility maps for 88 CLL samples from 55 patients measured by the ATAC-seq assay. We also performed ChIPmentation and RNA-seq profiling for ten representative samples. Based on the resulting data set, we devised and applied a bioinformatic method that links ...[more]

PMID: 27346425

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