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Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University

ABSTRACT: Organisation EGAO00000000132

PROVIDER: EGAO00000000132 | EGA |

REPOSITORIES: EGA

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Publications

Powerful identification of cis-regulatory SNPs in human primary monocytes using allele-specific gene expression.

Almlöf Jonas Carlsson JC Lundmark Per P Lundmark Anders A Ge Bing B Maouche Seraya S Göring Harald H H HH Liljedahl Ulrika U Enström Camilla C Brocheton Jessy J Proust Carole C Godefroy Tiphaine T Sambrook Jennifer G JG Jolley Jennifer J Crisp-Hihn Abigail A Foad Nicola N Lloyd-Jones Heather H Stephens Jonathan J Gwilliam Rhian R Rice Catherine M CM Hengstenberg Christian C Samani Nilesh J NJ Erdmann Jeanette J Schunkert Heribert H Pastinen Tomi T Deloukas Panos P Goodall Alison H AH Ouwehand Willem H WH Cambien François F Syvänen Ann-Christine AC

PloS one 20121226 12

A large number of genome-wide association studies have been performed during the past five years to identify associations between SNPs and human complex diseases and traits. The assignment of a functional role for the identified disease-associated SNP is not straight-forward. Genome-wide expression quantitative trait locus (eQTL) analysis is frequently used as the initial step to define a function while allele-specific gene expression (ASE) analysis has not yet gained a wide-spread use in diseas ...[more]

PMID: 23300628

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Project description:BackgroundIn 1985 medical schools were integrated into the Ministry of Health, and the Ministry of Health and Medical Education was created in Iran. Under this infrastructure education, research and service provision are unified, and it is expected that collaboration between researchers and decision makers become easier in such an integrated context.The question here is how the researchers behavior in the biggest medical university of the country towards collaboration is, i.e. how much do decision makers participate in different stages of research? Which factors affect it?MethodologyThe samples under study were all Tehran University of Medical Sciences (TUMS) completed research projects that had gotten grants in 2004 and were over by the time this study was done. Two questionnaires were designed for this study: i) the research checklist which was filled for 301 projects, ii) the researcher's questionnaire, which was sent to principle investigators, 208 of which were collected. Multiple linear regression analysis was used for evaluating the potential factors affecting individuals 'collaboration score'.ResultsOnly 2.2 percent of TUMS' projects initiated in 2004 have had collaboration as a joint PI or co-investigator from non-academic organizations. The principle investigators mean collaboration score was 2.09, where 6 was the total score. So the collaboration score obtained was 35%. The 'type of research' had significant association with the collaboration score which is shown in the linear regression; collaboration was seen more in clinical (p = 0.007) and health system researches (p = 0.001) as compared to basic research.ConclusionThe present study shows that not many individuals collaborated as co-investigators from outside the university. This finding shows that research policy makers need to introduce interventions in this field. And assessment of barriers to collaboration and its facilitating factors should be considered in order to make it actually happen.

Dataset Information

Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University

Publications

Powerful identification of cis-regulatory SNPs in human primary monocytes using allele-specific gene expression.

Similar Datasets

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