Dataset Information
MalariaGEN case-control study in the Gambia
Ontology highlight
ABSTRACT:
PROVIDER: EGAS00000000026 | EGA |
REPOSITORIES: EGA
Publications
Genome-wide and fine-resolution association analysis of malaria in West Africa.
Nature genetics 20090524 6
We report a genome-wide association (GWA) study of severe malaria in The Gambia. The initial GWA scan included 2,500 children genotyped on the Affymetrix 500K GeneChip, and a replication study included 3,400 children. We used this to examine the performance of GWA methods in Africa. We found considerable population stratification, and also that signals of association at known malaria resistance loci were greatly attenuated owing to weak linkage disequilibrium (LD). To investigate possible soluti ...[more]
