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T1DGC GWAS 1958 British Birth Cohort controls

ABSTRACT: T1DGC genome-wide case-control association study for Type 1 Diabetes (T1D) using the 1958 British Birth Cohort as controls. The cases for this study are made available from the NCBI dbGAP.

PROVIDER: EGAS00000000038 | EGA |

REPOSITORIES: EGA

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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

Barrett Jeffrey C JC Clayton David G DG Concannon Patrick P Akolkar Beena B Cooper Jason D JD Erlich Henry A HA Julier Cécile C Morahan Grant G Nerup Jørn J Nierras Concepcion C Plagnol Vincent V Pociot Flemming F Schuilenburg Helen H Smyth Deborah J DJ Stevens Helen H Todd John A JA Walker Neil M NM Rich Stephen S SS

Nature genetics 20090510 6

Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P < 10(-6)). After excluding previously reported association ...[more]

PMID: 19430480

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WTCCC2 project controls - 1958 British Birth Cohort and National Blood Service

Project description:WTCCC2 project controls - 1958 British Birth Cohort and National Blood Service

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1958 British Birth Cohort

Project description:The National Child Development Study (NCDS) - also known as the 1958 British Birth Cohort (1958BC) - is a continuing, multi-disciplinary longitudinal study which takes as its subjects all the people born in one week in March 1958 in England, Scotland and Wales. The resource is used widely for research in genetic and genomic epidemiology - in particular as a platform for genetic association studies. Data are released under various Data Access Agreements. (1) Data users requesting genotype data only should apply to the Wellcome Trust Case Control consortium Data Access Committee (EGAC00000000001). (2) Those requesting phenotype data only should apply to the (ESRC) UK Data Archive (for more information please email to help@esds.ac.uk). (3) Those requesting linked genotype and phenotype data should apply to the Access Committee for the CLS Cohorts (for more information email to cohort1958@le.ac.uk).

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Phakopsora pachyrhizi strain:CMES 1958

Project description:Phakopsora pachyrhizi CMES 1958 Resequencing

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WTCCC case-control study for Type 1 Diabetes - Combined Controls

Project description:WTCCC genome-wide case-control association study for Type 1 Diabetes (T1D) using six disease collections together with the 1958 British Birth Cohort and the UK National Blood Service collections as controls.

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Lifecourse social position and D-dimer; findings from the 1958 British birth cohort.

Project description:The aim is to examine the association of lifecourse socioeconomic position (SEP) on circulating levels of D-dimer. Data from the 1958 British birth cohort were used, social class was determined at three stages of respondents' life: at birth, at 23 and at 42 years. A cumulative indicator score of SEP (CIS) was calculated ranging from 0 (always in the highest social class) to 9 (always in the lowest social class). In men and women, associations were observed between CIS and D-dimer (P<0.05). Thus, the respondents in more disadvantaged social classes had elevated levels of D-dimer compared to respondents in less disadvantaged social class. In multivariate analyses, the association of disadvantaged social position with D-dimer was largely explained by fibrinogen, C-reactive protein and von Willebrand Factor in women, and additionally by smoking, alcohol consumption and physical activity in men. Socioeconomic circumstances across the lifecourse at various stages also contribute independently to raised levels of D-dimer in middle age in women only. Risk exposure related to SEP accumulates across life and contributes to raised levels of D-dimer. The association of haemostatic markers and social differences in health may be mediated by inflammatory and other markers.

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Does amblyopia affect educational, health, and social outcomes? Findings from 1958 British birth cohort.

Project description:ObjectiveTo determine any association of amblyopia with diverse educational, health, and social outcomes in order to inform current debate about population screening for this condition.Design, setting, and participantsComparison of 8432 people with normal vision in each eye with 429 (4.8%) people with amblyopia (childhood unilateral reduced acuity when tested with correction and unaccounted for by eye disease) from the 1958 British birth cohort, with respect to subsequent health and social functioning.ResultsNo functionally or clinically significant differences existed between people with and without amblyopia in educational outcomes, behavioural difficulties or social maladjustment, participation in social activities, unintended injuries (school, workplace, or road traffic accidents as driver), general or mental health and mortality, paid employment, or occupation based social class trajectories.ConclusionsIt may be difficult to distinguish, at population level, between the lives of people with amblyopia and those without, in terms of several important outcomes. A pressing need exists for further concerted research on what it means to have amblyopia and, specifically, how this varies with severity and how it changes with treatment, so that screening programmes can best serve those who have the most to gain from early identification.

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Childhood adversity as a risk for cancer: findings from the 1958 British birth cohort study.

Project description:To analyse whether Adverse Childhood Experiences (ACE) are associated with an increased risk of cancer.The National child development study (NCDS) is a prospective birth cohort study with data collected over 50 years. The NCDS included all live births during one week in 1958 (n=18558) in Great Britain. Self-reported cancer incidence was based on 444 participants reporting having had cancer at some point and 5694 reporting never having cancer. ACE was measured using reports of: 1) child in care, 2) physical neglect, 3) child's or family's contact with the prison service, 4) parental separation due to divorce, death or other, 5) family experience of mental illness & 6) family experience of substance abuse. The resulting variable had three categories, no ACEs/ one ACE/ 2+ACEs and was used to test for a relationship with cancer. Information on socioeconomic characteristics, pregnancy and birth were extracted as potential confounders. Information on adult health behaviours, socioeconomic environment, psychological state and age at first pregnancy were added to the models. Multivariate models were run using multiply-imputed data to account for missing data in the cohort.The odds of having a cancer before 50 y among women increased twofold for those who had 2+ ACEs versus those with no ACEs, after adjusting for adult factors and early life confounders (OR: 2.1, 95% CI: 1.42-3.21, p<0.001).These findings suggest that cancer risk may be influenced by exposure to stressful conditions and events early on in life. This is potentially important in furthering our understanding of cancer aetiology, and consequently in redirecting scientific research and developing appropriate prevention policies.

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Nutomonas longa strain:CCAP 1958/5

Project description:Nutomonas longa strain:CCAP 1958/5 Transcriptome or Gene expression

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Adverse childhood experiences and physiological wear-and-tear in midlife: Findings from the 1958 British birth cohort.

Project description:Allostatic load (AL) is a measure of overall physiological wear-and-tear over the life course, which could partially be the consequence of early life exposures. AL could allow a better understanding of the potential biological pathways playing a role in the construction of the social gradient in adult health. To explore the biological embedding hypothesis, we examined whether adverse childhood experiences (ACEs) are associated with elevated AL in midlife. We used imputed data on 3,782 women and 3,753 men of the National Child Development Study in Britain followed up seven times. ACEs were measured using prospective data collected at ages 7, 11, and 16. AL was operationalized using data from the biomedical survey collected at age 44 on 14 parameters representing four biological systems. We examined the role of adult health behaviors, body mass index (BMI), and socioeconomic status as potential mediators using a path analysis. ACEs were associated with higher AL for both men and women after adjustment for early life factors and childhood pathologies. The path analysis showed that the association between ACEs and AL was largely explained by early adult factors at age 23 and 33. For men, the total mediated effect was 59% (for two or more ACEs) via health behaviors, education level, and wealth. For women, the mediated effect represented 76% (for two or more ACEs) via smoking, BMI, education level, and wealth. Our results indicate that early psychosocial stress has an indirect lasting impact on physiological wear-and-tear via health behaviors, BMI, and socioeconomic factors in adulthood.

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Is cardiorespiratory fitness associated with cognitive outcomes in mid-adulthood? Findings from the 1958 British birth cohort.

Project description:Identifying causal factors to intervene on to delay age-related declines in cognitive function is urgently needed. We examined associations between non-exercise testing cardiorespiratory fitness (NETCRF; estimated using sex, age, body mass index, resting heart rate, and physical activity) at 45 years and cognitive function outcomes (immediate and delayed verbal memory; verbal fluency; visual processing speed) at 50 years in 8130 participants from the 1958 British birth cohort. In unadjusted models, higher NETCRF was associated with better cognitive function across all outcomes. When adjusted for confounding factors, associations disappeared. In this cohort, associations between 45 years NETCRF and 50 years cognitive function likely result from confounding factors.

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