WTCCC2 project controls - 1958 British Birth Cohort and National Blood Service
Ontology highlight
ABSTRACT:
PROVIDER: EGAS00000000028 | EGA |
REPOSITORIES: EGA
Publications
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
Barrett Jeffrey C JC Lee James C JC Lees Charles W CW Prescott Natalie J NJ Anderson Carl A CA Phillips Anne A Wesley Emma E Parnell Kirstie K Zhang Hu H Drummond Hazel H Nimmo Elaine R ER Massey Dunecan D Blaszczyk Kasia K Elliott Timothy T Cotterill Lynn L Dallal Helen H Lobo Alan J AJ Mowat Craig C Sanderson Jeremy D JD Jewell Derek P DP Newman William G WG Edwards Cathryn C Ahmad Tariq T Mansfield John C JC Satsangi Jack J Parkes Miles M Mathew Christopher G CG Donnelly Peter P Peltonen Leena L Blackwell Jenefer M JM Bramon Elvira E Brown Matthew A MA Casas Juan P JP Corvin Aiden A Craddock Nicholas N Deloukas Panos P Duncanson Audrey A Jankowski Janusz J Markus Hugh S HS Mathew Christopher G CG McCarthy Mark I MI Palmer Colin N A CN Plomin Robert R Rautanen Anna A Sawcer Stephen J SJ Samani Nilesh N Trembath Richard C RC Viswanathan Anath C AC Wood Nicholas N Spencer Chris C A CC Barrett Jeffrey C JC Bellenguez Céline C Davison Daniel D Freeman Colin C Strange Amy A Donnelly Peter P Langford Cordelia C Hunt Sarah E SE Edkins Sarah S Gwilliam Rhian R Blackburn Hannah H Bumpstead Suzannah J SJ Dronov Serge S Gillman Matthew M Gray Emma E Hammond Naomi N Jayakumar Alagurevathi A McCann Owen T OT Liddle Jennifer J Perez Marc L ML Potter Simon C SC Ravindrarajah Radhi R Ricketts Michelle M Waller Matthew M Weston Paul P Widaa Sara S Whittaker Pamela P Deloukas Panos P Peltonen Leena L Mathew Christopher G CG Blackwell Jenefer M JM Brown Matthew A MA Corvin Aiden A McCarthy Mark I MI Spencer Chris C A CC Attwood Antony P AP Stephens Jonathan J Sambrook Jennifer J Ouwehand Willem H WH McArdle Wendy L WL Ring Susan M SM Strachan David P DP
Nature genetics 20091115 12
Ulcerative colitis is a common form of inflammatory bowel disease with a complex etiology. As part of the Wellcome Trust Case Control Consortium 2, we performed a genome-wide association scan for ulcerative colitis in 2,361 cases and 5,417 controls. Loci showing evidence of association at P < 1 x 10(-5) were followed up by genotyping in an independent set of 2,321 cases and 4,818 controls. We find genome-wide significant evidence of association at three new loci, each containing at least one bio ...[more]
