Ontology highlight
ABSTRACT:
PROVIDER: EGAS00000000040 | EGA |
REPOSITORIES: EGA
Shah Sohrab P SP Köbel Martin M Senz Janine J Morin Ryan D RD Clarke Blaise A BA Wiegand Kimberly C KC Leung Gillian G Zayed Abdalnasser A Mehl Erika E Kalloger Steve E SE Sun Mark M Giuliany Ryan R Yorida Erika E Jones Steven S Varhol Richard R Swenerton Kenneth D KD Miller Dianne D Clement Philip B PB Crane Colleen C Madore Jason J Provencher Diane D Leung Peter P DeFazio Anna A Khattra Jaswinder J Turashvili Gulisa G Zhao Yongjun Y Zeng Thomas T Glover J N Mark JN Vanderhyden Barbara B Zhao Chengquan C Parkinson Christine A CA Jimenez-Linan Mercedes M Bowtell David D L DD Mes-Masson Anne-Marie AM Brenton James D JD Aparicio Samuel A SA Boyd Niki N Hirst Martin M Gilks C Blake CB Marra Marco M Huntsman David G DG
The New England journal of medicine 20090610 26
<h4>Background</h4>Granulosa-cell tumors (GCTs) are the most common type of malignant ovarian sex cord-stromal tumor (SCST). The pathogenesis of these tumors is unknown. Moreover, their histopathological diagnosis can be challenging, and there is no curative treatment beyond surgery.<h4>Methods</h4>We analyzed four adult-type GCTs using whole-transcriptome paired-end RNA sequencing. We identified putative GCT-specific mutations that were present in at least three of these samples but were absent ...[more]