Genomics

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WTCCC2 Pharmacogenomic Response to Statins study

ABSTRACT: A WTCCC2 project genome-wide study for pharmacogenomic response to statins (PR) in individuals from Scotland.

PROVIDER: EGAS00000000121 | EGA |

REPOSITORIES: EGA

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Publications

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.

Zhou Kaixin K   Bellenguez Celine C   Spencer Chris C A CC   Bennett Amanda J AJ   Coleman Ruth L RL   Tavendale Roger R   Hawley Simon A SA   Donnelly Louise A LA   Schofield Chris C   Groves Christopher J CJ   Burch Lindsay L   Carr Fiona F   Strange Amy A   Freeman Colin C   Blackwell Jenefer M JM   Bramon Elvira E   Brown Matthew A MA   Casas Juan P JP   Corvin Aiden A   Craddock Nicholas N   Deloukas Panos P   Dronov Serge S   Duncanson Audrey A   Edkins Sarah S   Gray Emma E   Hunt Sarah S   Jankowski Janusz J   Langford Cordelia C   Markus Hugh S HS   Mathew Christopher G CG   Plomin Robert R   Rautanen Anna A   Sawcer Stephen J SJ   Samani Nilesh J NJ   Trembath Richard R   Viswanathan Ananth C AC   Wood Nicholas W NW   Harries Lorna W LW   Hattersley Andrew T AT   Doney Alex S F AS   Colhoun Helen H   Morris Andrew D AD   Sutherland Calum C   Hardie D Grahame DG   Peltonen Leena L   McCarthy Mark I MI   Holman Rury R RR   Palmer Colin N A CN   Donnelly Peter P   Pearson Ewan R ER  

Nature genetics 20101226 2

Metformin is the most commonly used pharmacological therapy for type 2 diabetes. We report a genome-wide association study for glycemic response to metformin in 1,024 Scottish individuals with type 2 diabetes with replication in two cohorts including 1,783 Scottish individuals and 1,113 individuals from the UK Prospective Diabetes Study. In a combined meta-analysis, we identified a SNP, rs11212617, associated with treatment success (n = 3,920, P = 2.9 × 10(-9), odds ratio = 1.35, 95% CI 1.22-1.4  ...[more]

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