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Genetic mechanisms of resistance to chemotherapy in breast cancer

ABSTRACT: Resistance towards chemotherapy is one of the main causes of treatment failure and death among breast cancer patients. The main objective of this project is to identify genetic mechanisms causing some breast cancer patients not to respond to a particluar type of chemotherapy (epirubicin) while other patients respond very well to the same treatment. In the project we will perform genome / exome sequencing of a selection of breast cancer patients (n=30). These patients are drawn from a cohort where all patients have recieved treatment with epirubicin monotherapy before surgical removal of a locally advanced breast tumour, and where all patients have been subjected to objective evaluation of the response to the therapy. Subsequent to sequencing, we will analyse the data and compare with the clinical data for each patient (object response to therapy). The main aim being to identify mutations that are associated with resistance to epirubicin. Identification of mutations with strong predictive value, may have a direct impact on cancer treatment since it opens the possibility for genetic testing of a tumour, and desicion on which drug is likely to work best, prior to treatment start.

PROVIDER: EGAS00001000276 | EGA |

REPOSITORIES: EGA

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EGAS00001000276-sc-20121031 - samples

Project description:Resistance towards chemotherapy is one of the main causes of treatment failure and death among breast cancer patients.The main objective of this project is to identify genetic mechanisms causing some breast cancer patients not to respond to a particluar type of chemotherapy (epirubicin) while other patients respond very well to the same treatment. In the project we will perform genome / exome sequencing of a selection of breast cancer patients (n=30). These patients are drawn from a cohort where all patients have recieved treatment with epirubicin monotherapy before surgical removal of a locally advanced breast tumour, and where all patients have been subjected to objective evaluation of the response to the therapy. Subsequent to sequencing, we will analyse the data and compare with the clinical data for each patient (object response to therapy). The main aim being to identify mutations that are associated with resistance to epirubicin. Identification of mutations with strong predictive value, may have a direct impact on cancer treatment since it opens the possibility for genetic testing of a tumour, and desicion on which drug is likely to work best, prior to treatment start.

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Global gene expression analysis of anthracycline-resistant breast cancer cell lines

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Mkango2019 - Dynamics of Breast Cancer under DifferentRates of Chemoradiotherapy

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Global gene expression analysis of anthracycline-resistant breast cancer cell lines

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Expression profiling of human primary breast cancer tissue before treatment with gemcitabine, epirubicine and docetaxel

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S080_BrCaRes_Schneeweiss et al.

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2014-02-01 | E-TABM-1186 | biostudies-arrayexpress

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