Genomics

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Whole-genome sequencing analysis of low-grade astrocytomas within the ICGC PedBrain Tumor Project

ABSTRACT: In order to investigate the full range of genetic alterations contributing to the tumourigenesis of low-grade astrocytoma, we have conducted a next-generation sequencing-based analysis on a large series of matched tumor-normal pairs. This study, conducted by the International Cancer Genome Consortium PedBrain Tumor Project (ICGC PedBrain, http://www.pedbraintumor.org/), has revealed multiple new insights into the biological basis of this tumor entity.

PROVIDER: EGAS00001000381 | EGA |

REPOSITORIES: EGA

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Publications

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.

Jones David T W DT   Hutter Barbara B   Jäger Natalie N   Korshunov Andrey A   Kool Marcel M   Warnatz Hans-Jörg HJ   Zichner Thomas T   Lambert Sally R SR   Ryzhova Marina M   Quang Dong Anh Khuong DA   Fontebasso Adam M AM   Stütz Adrian M AM   Hutter Sonja S   Zuckermann Marc M   Sturm Dominik D   Gronych Jan J   Lasitschka Bärbel B   Schmidt Sabine S   Seker-Cin Huriye H   Witt Hendrik H   Sultan Marc M   Ralser Meryem M   Northcott Paul A PA   Hovestadt Volker V   Bender Sebastian S   Pfaff Elke E   Stark Sebastian S   Faury Damien D   Schwartzentruber Jeremy J   Majewski Jacek J   Weber Ursula D UD   Zapatka Marc M   Raeder Benjamin B   Schlesner Matthias M   Worth Catherine L CL   Bartholomae Cynthia C CC   von Kalle Christof C   Imbusch Charles D CD   Radomski Sylwester S   Lawerenz Chris C   van Sluis Peter P   Koster Jan J   Volckmann Richard R   Versteeg Rogier R   Lehrach Hans H   Monoranu Camelia C   Winkler Beate B   Unterberg Andreas A   Herold-Mende Christel C   Milde Till T   Kulozik Andreas E AE   Ebinger Martin M   Schuhmann Martin U MU   Cho Yoon-Jae YJ   Pomeroy Scott L SL   von Deimling Andreas A   Witt Olaf O   Taylor Michael D MD   Wolf Stephan S   Karajannis Matthias A MA   Eberhart Charles G CG   Scheurlen Wolfram W   Hasselblatt Martin M   Ligon Keith L KL   Kieran Mark W MW   Korbel Jan O JO   Yaspo Marie-Laure ML   Brors Benedikt B   Felsberg Jörg J   Reifenberger Guido G   Collins V Peter VP   Jabado Nada N   Eils Roland R   Lichter Peter P   Pfister Stefan M SM  

Nature genetics 20130630 8

Pilocytic astrocytoma, the most common childhood brain tumor, is typically associated with mitogen-activated protein kinase (MAPK) pathway alterations. Surgically inaccessible midline tumors are therapeutically challenging, showing sustained tendency for progression and often becoming a chronic disease with substantial morbidities. Here we describe whole-genome sequencing of 96 pilocytic astrocytomas, with matched RNA sequencing (n = 73), conducted by the International Cancer Genome Consortium (  ...[more]

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