Genome-wide mutation analysis of germinal-center B-cell derived lymphomas within the ICGC MMML-Seq Consortium
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ABSTRACT:
PROVIDER: EGAS00001000394 | EGA |
REPOSITORIES: EGA
Publications
Hypermutation of the inactive X chromosome is a frequent event in cancer.
Jäger Natalie N Schlesner Matthias M Jones David T W DT Raffel Simon S Mallm Jan-Philipp JP Junge Kristin M KM Weichenhan Dieter D Bauer Tobias T Ishaque Naveed N Kool Marcel M Northcott Paul A PA Korshunov Andrey A Drews Ruben M RM Koster Jan J Versteeg Rogier R Richter Julia J Hummel Michael M Mack Stephen C SC Taylor Michael D MD Witt Hendrik H Swartman Benedict B Schulte-Bockholt Dietrich D Sultan Marc M Yaspo Marie-Laure ML Lehrach Hans H Hutter Barbara B Brors Benedikt B Wolf Stephan S Plass Christoph C Siebert Reiner R Trumpp Andreas A Rippe Karsten K Lehmann Irina I Lichter Peter P Pfister Stefan M SM Eils Roland R
Cell 20131017 3
Mutation is a fundamental process in tumorigenesis. However, the degree to which the rate of somatic mutation varies across the human genome and the mechanistic basis underlying this variation remain to be fully elucidated. Here, we performed a cross-cancer comparison of 402 whole genomes comprising a diverse set of childhood and adult tumors, including both solid and hematopoietic malignancies. Surprisingly, we found that the inactive X chromosome of many female cancer genomes accumulates on av ...[more]
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