Dataset Information
Whole-Genome Sequencing of 128 Ashkenazi Jewish individuals
Ontology highlight
ABSTRACT:
PROVIDER: EGAS00001000664 | EGA |
REPOSITORIES: EGA
Publications
Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins.
Nature communications 20140909
The Ashkenazi Jewish (AJ) population is a genetic isolate close to European and Middle Eastern groups, with genetic diversity patterns conducive to disease mapping. Here we report high-depth sequencing of 128 complete genomes of AJ controls. Compared with European samples, our AJ panel has 47% more novel variants per genome and is eightfold more effective at filtering benign variants out of AJ clinical genomes. Our panel improves imputation accuracy for AJ SNP arrays by 28%, and covers at least ...[more]
