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Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing

ABSTRACT: In this study, we employed massively parallel sequencing technology to identify miRNAs expressed in B-cells from Ashkenazi Jewish centenarians, i.e., those living to a hundred and a human model of exceptional longevity, and younger controls without a family history of longevity. With data from 26.7 million reads comprising 9.4x108 bp from 3 centenarian and 3 control individuals, we discovered a total of 276 known miRNAs and 8 unknown miRNAs ranging several orders of magnitude in expression levels. A total of 22 miRNAs were found to be significantly upregulated, with only 2 miRNAs downregulated, in centenarians as compared to controls.

ORGANISM(S): Homo sapiens

PROVIDER: GSE32493 | GEO | 2012/06/01

SECONDARY ACCESSION(S): PRJNA147763

REPOSITORIES: GEO

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