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Diverse modes of genomic alterations in hepatocellular carcinoma

ABSTRACT: Hepatocellular carcinoma is the most prevalent type of liver cancer. We intended to study the genomic landscape of this disease. We conducted whole-genome, exome and transcriptome sequencing for 42 patients. We show diverse modes in which the HCC genome is affected in these patients, including well-known and novel mutations, structural variations, and Hepatitis B-virus integration into the genome.

PROVIDER: EGAS00001000824 | EGA |

REPOSITORIES: EGA

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Diverse modes of genomic alteration in hepatocellular carcinoma.

Jhunjhunwala Suchit S Jiang Zhaoshi Z Stawiski Eric W EW Gnad Florian F Liu Jinfeng J Mayba Oleg O Du Pan P Diao Jingyu J Johnson Stephanie S Wong Kwong-Fai KF Gao Zhibo Z Li Yingrui Y Wu Thomas D TD Kapadia Sharookh B SB Modrusan Zora Z French Dorothy M DM Luk John M JM Seshagiri Somasekar S Zhang Zemin Z

Genome biology 20140826 8

<h4>Background</h4>Hepatocellular carcinoma (HCC) is a heterogeneous disease with high mortality rate. Recent genomic studies have identified TP53, AXIN1, and CTNNB1 as the most frequently mutated genes. Lower frequency mutations have been reported in ARID1A, ARID2 and JAK1. In addition, hepatitis B virus (HBV) integrations into the human genome have been associated with HCC.<h4>Results</h4>Here, we deep-sequence 42 HCC patients with a combination of whole genome, exome and transcriptome sequenc ...[more]

PMID: 25159915

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