Ontology highlight
ABSTRACT:
PROVIDER: EGAS00001000927 | EGA |
REPOSITORIES: EGA
Bioinformatics (Oxford, England) 20130709 18
<h4>Motivation</h4>With the advent of relatively affordable high-throughput technologies, DNA sequencing of cancers is now common practice in cancer research projects and will be increasingly used in clinical practice to inform diagnosis and treatment. Somatic (cancer-only) single nucleotide variants (SNVs) are the simplest class of mutation, yet their identification in DNA sequencing data is confounded by germline polymorphisms, tumour heterogeneity and sequencing and analysis errors. Four rece ...[more]